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BACKGROUNDIn the medical literature many analyses of outcomes of sarcoma patients were performed without regard to the problem of “competing risks.”
METHODSWe analyzed local relapse–free and metastasis‐free survival in a population of 3255 adult patients with a primary soft‐tissue sarcoma (STS) included in the French Sarcoma Group database. Cumulative incidence of local and metastatic relapse was...
BACKGROUNDThe neutrophil‐to‐lymphocyte ratio (NLR), a marker of inflammation, has been reported to be a poor prognostic indicator in prostate cancer. Here we explore the use of the NLR to establish a simple prognostic score for men with metastatic castration‐resistant prostate cancer (mCRPC) treated with docetaxel. METHODS: In the training cohort, the NLR and other known prognostic variables were...
BACKGROUNDThe development of novel therapeutic approaches for cancer therapy is important, especially for tumors that have poor response or develop resistance to standard chemotherapy and radiation. We discovered that noninvasive radiofrequency (RF) fields can affect cancer cells but not normal cells, inhibit progression of tumors in mice, and enhance the anticancer effects of chemotherapy. However,...
BACKGROUNDLong noncoding RNAs (lncRNAs) play a crucial role in tumorigenesis. However, the value of lncRNAs in the diagnosis of gastric cancer remains unknown. To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of gastric tumorigenesis.
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BACKGROUNDSubstance use disorder in patients with cancer has implications for outcomes. The objective of this study was to analyze the effects of the type and timing of substance use on outcomes in elderly Medicare recipients with advanced prostate cancer.
METHODSThis was an observational cohort study using Surveillance, Epidemiology, and End Results (SEER)‐Medicare linked data from 2000 to 2009...
BACKGROUNDIt has been demonstrated that regular exercise improves the quality of life in patients undergoing treatment for lung cancer and has been associated with reductions in cancer‐specific mortality in patients with colon and breast cancer. The direct effects of cardiovascular exercise on lung cancer tumor biology, however, remain unknown. The authors evaluated the effects of cardiovascular exercise...
BACKGROUNDRecurrence and toxicity occur commonly among patients with rectal cancer who are treated with 5‐fluorouracil (5‐FU). The authors hypothesized that genetic variation in folate‐metabolizing genes could play a role in interindividual variability. The objective of the current study was to evaluate the associations between genetic variants in folate‐metabolizing genes and clinical outcomes among...
BACKGROUNDThe current study was conducted to evaluate the long‐term results of irradiation with carbon ions in a raster scanning technique in patients with skull base chordomas.
METHODSBetween 1998 and 2008, a total of 155 patients (76 men and 79 women) with a median age of 48 years (range, 15 years‐85 years) were irradiated with carbon ions using a raster scan technique. The irradiation was performed...
BackgroundIt has been reported that interferon‐γ (IFN‐γ)–induced inflammatory markers, such as circulating neopterin and kynurenine‐to‐tryptophan ratio (KTR), are increased in patients with cancer and are also a predictor of poor prognosis. However, whether baseline levels of these makers are associated with subsequent cancer risk in the general population remains unknown.
MethodsWe conducted a prospective...
BACKGROUNDFactors contributing to the lower likelihood of urologist follow‐up among African American (AA) men diagnosed with prostate cancer may not be strictly related to patient factors. The authors investigated the relationship between crime, poverty, and poor housing, among others, and postdiagnosis urologist visits among AA and white men.
METHODSThe authors used linked cancer registry and Medicare...
BACKGROUNDThe primary objective of this study was to determine the safety and maximum tolerated dose (MTD) of the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) (a recombinant antimesothelin immunotoxin consisting of a murine antimesothelin variable antibody fragment [Fv] linked to PE38, a truncated portion of Pseudomonas exotoxin A) in combination with pemetrexed and cisplatin in chemotherapy‐naive...
BACKGROUNDThe National Comprehensive Cancer Network guidelines recommend that patients with surgically resected head and neck cancers that have adverse pathologic features should receive adjuvant therapy in the form of radiotherapy (RT) or chemoradiation (CRT). To the authors' knowledge, the current study is the first analysis of temporal trends and use patterns of adjuvant therapy for these patients...
Recently, the century‐old idea of targeting cancer with viruses (oncolytic viruses) has come of age, and promise has been documented in early stage and several late‐stage clinical trials in a variety of cancers. Although originally prized for their direct tumor cytotoxicity (oncolytic virotherapy), recently, the proinflammatory and immunogenic effects of viral tumor infection (oncolytic immunotherapy...
BACKGROUNDEpidemiological studies have shown prostate cancer (PC) survivors are at an increased risk of suicide compared with the general population, but to the authors' knowledge very little is known regarding what factors are associated with this increased risk. The current study examined the prevalence of suicidal ideation (SI) and its association with cancer treatment and posttreatment physical...
Medullary thyroid cancer (MTC) is an aggressive form of thyroid cancer that occurs in both heritable and sporadic forms. Discovery that mutations in the rearranged during transfection (RET) proto‐oncogene predispose to familial cases of this disease has allowed for presymptomatic identification of gene carriers and prophylactic surgery to improve the prognosis of these patients. A significant number...
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